Tsutomu Yoshikawa Selected Research

Aldosterone

4/2015	Rationale and Design of the Double-Blind, Randomized, Placebo-Controlled Multicenter Trial on Efficacy of Early Initiation of Eplerenone Treatment in Patients with Acute Heart Failure (EARLIER).
5/2005	Persistent cardiac aldosterone synthesis in angiotensin II type 1A receptor-knockout mice after myocardial infarction.

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Tsutomu Yoshikawa Research Topics

Disease

56	Heart Failure 01/2023 - 01/2002
17	Myocardial Infarction 02/2019 - 01/2003
10	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 12/2016 - 01/2002
7	Fibrosis (Cirrhosis) 01/2022 - 10/2004
6	Cardiac Sudden Death (Sudden Cardiac Arrest) 01/2020 - 01/2002
6	Ventricular Tachycardia 01/2018 - 01/2002
6	Ventricular Remodeling 01/2011 - 04/2003
5	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 11/2008
5	Death (Near-Death Experience) 01/2019 - 02/2009
5	Atrial Fibrillation 01/2011 - 11/2002
5	Infarction (Infarctions) 02/2009 - 01/2003
4	Anemia 06/2021 - 05/2010
4	Abdominal Aortic Aneurysm 05/2012 - 07/2011
4	Heart Rupture 12/2010 - 01/2003
3	Hyponatremia 10/2019 - 01/2018
3	Chronic Renal Insufficiency 08/2019 - 08/2010
3	Coronary Artery Disease (Coronary Atherosclerosis) 01/2019 - 11/2002
3	Sudden Death 01/2018 - 09/2002
3	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 01/2018 - 01/2016
3	Necrosis 08/2011 - 02/2009
3	Aortic Dissection 11/2010 - 06/2005
3	ST Elevation Myocardial Infarction 09/2010 - 11/2009
3	Convalescence 05/2010 - 10/2008
2	Chest Pain (Chest Pains) 02/2019 - 01/2009
2	Chronic Obstructive Pulmonary Disease (COPD) 01/2019 - 01/2016
2	Ventricular Fibrillation 01/2018 - 11/2009
2	Inflammation (Inflammations) 01/2015 - 08/2011
2	Cardiomyopathies (Cardiomyopathy) 01/2015 - 03/2004
2	Diabetic Cardiomyopathies 01/2014 - 01/2011
2	Left Ventricular Dysfunction 01/2014 - 12/2010
2	Myocarditis (Carditis) 05/2012 - 04/2009
2	Aneurysm (Aneurysms) 08/2011 - 07/2011
2	Obesity 08/2011 - 01/2011
2	Insulin Resistance 08/2011 - 01/2011
2	Hypertension (High Blood Pressure) 02/2011 - 11/2002
2	Neoplasms (Cancer) 10/2008 - 09/2008
2	Mitral Valve Insufficiency (Mitral Regurgitation) 01/2007 - 11/2002
2	Cardiomegaly (Heart Hypertrophy) 09/2006 - 05/2003
2	Familial Primary Pulmonary Hypertension 04/2005 - 10/2004

Drug/Important Bio-Agent (IBA)

16	C-Reactive ProteinIBA 02/2019 - 01/2003
14	AutoantibodiesIBA 12/2016 - 01/2002
10	Brain Natriuretic Peptide (Natrecor)FDA Link 08/2019 - 08/2004
8	Carvedilol (Coreg)FDA LinkGeneric 03/2020 - 10/2003
7	CytokinesIBA 03/2012 - 09/2002
5	DiureticsIBA 01/2021 - 01/2009
5	Messenger RNA (mRNA)IBA 08/2011 - 10/2004
5	Adenosine Triphosphatases (ATPase)IBA 01/2011 - 01/2002
4	Eplerenone (Inspra)FDA LinkGeneric 01/2022 - 01/2014
4	Urea (Carbamide)FDA LinkGeneric 12/2019 - 01/2016
4	NitrogenIBA 12/2019 - 01/2016
4	GadoliniumIBA 01/2018 - 01/2015
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2012 - 07/2006
4	EnzymesIBA 10/2011 - 11/2002
4	Metoprolol (Toprol-XL)FDA LinkGeneric 08/2010 - 10/2003
3	Mineralocorticoid Receptor AntagonistsIBA 01/2023 - 12/2017
3	Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)IBA 10/2022 - 01/2018
3	Angiotensin Receptors (Angiotensin II Receptor)IBA 01/2022 - 01/2004
3	Hemoglobins (Hemoglobin)IBA 06/2021 - 01/2018
3	Indicators and Reagents (Reagents)IBA 01/2020 - 01/2015
3	Biomarkers (Surrogate Marker)IBA 01/2018 - 01/2009
3	Proteins (Proteins, Gene)FDA Link 05/2012 - 02/2009
3	Epoprostenol (Prostacyclin)FDA LinkGeneric 01/2012 - 10/2004
3	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 08/2011 - 10/2008
3	Norepinephrine (Noradrenaline)FDA LinkGeneric 05/2010 - 01/2002
3	beta Adrenergic ReceptorsIBA 05/2006 - 05/2003
2	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2023 - 01/2022
2	Uric Acid (Urate)IBA 11/2020 - 01/2020
2	CreatinineIBA 12/2019 - 08/2019
2	SodiumIBA 10/2019 - 01/2016
2	CatecholaminesIBA 02/2019 - 12/2016
2	Tryptophan (L-Tryptophan)FDA Link 12/2016 - 01/2011
2	AldosteroneIBA 04/2015 - 05/2005
2	Type 1 Angiotensin ReceptorIBA 01/2014 - 05/2005
2	Troponin T (Troponin T1)IBA 01/2014 - 05/2010
2	Cholinergic ReceptorsIBA 05/2012 - 07/2004
2	AntibodiesIBA 05/2012 - 04/2009
2	Interleukin-10 (Interleukin 10)IBA 03/2012 - 07/2006
2	human NPPA protein (carperitide)IBA 01/2012 - 11/2008
2	Glucose (Dextrose)FDA LinkGeneric 08/2011 - 01/2011
2	Matrix Metalloproteinases (MMPs)IBA 07/2011 - 05/2003
2	HMGB1 Protein (HMG1)IBA 05/2011 - 02/2009
2	omega-Chloroacetophenone (Mace)IBA 03/2011 - 05/2010
2	CalciumIBA 01/2011 - 04/2009
2	Muscarinic M2 ReceptorIBA 01/2011 - 04/2009
2	Troponin IIBA 01/2011 - 04/2009
2	Collagen Type I (Type I Collagen)IBA 01/2011 - 10/2004
2	Immunoglobulin G (IgG)IBA 01/2011 - 07/2010
2	Malondialdehyde (Propanedial)IBA 05/2010 - 12/2008
2	Interleukin-6 (Interleukin 6)IBA 05/2010 - 12/2008
2	LDL Lipoproteins (beta Lipoproteins)IBA 05/2010 - 12/2008
2	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 10/2008 - 10/2004
2	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 10/2008 - 02/2005
2	Transforming Growth Factor beta1 (TGF beta 1)IBA 10/2008 - 10/2004
2	Radioisotopes (Radionuclides)IBA 10/2005 - 10/2003
2	Sildenafil Citrate (Viagra)FDA Link 04/2005 - 10/2004
2	CollagenIBA 02/2005 - 10/2004
2	ImmunosorbentsIBA 07/2004 - 11/2002

Therapy/Procedure

25	Therapeutics 01/2023 - 09/2002
4	Patient Readmission 06/2021 - 01/2019
2	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 01/2020 - 01/2018